Each person has a protective blood barrier lining the blood vessels in the brain to restrict the passage of large toxic substances from the bloodstream into the brain.
“The blood-brain barrier has been a persistent obstacle to delivering valuable therapies to treat disease such as tumours,” said Dr Todd Mainprize, principal investigator of the study and Neurosurgeon at Sunnybrook Health Sciences Centre in Canada. “We are encouraged that we were able to temporarily open this barrier in a patient to deliver chemotherapy directly to the brain tumour,” he said. Once the barrier was opened, the chemotherapy deposited into the targeted regions.